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phenol toxicity in cats

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Berjé is a family-owned business that has been in operation for six decades. 1. The oral bioavailability of aspirin may vary because of differences in drug formulation. It is a colorless-to-white solid when pure. Phenol is both a manufactured chemical and a natural substance. Both of these substances are very toxic, and for someone who is injecting 20 units of insulin per day, means also 300 ppm of phenol per day and 344 ppm of m-cresol. Although not all of these side effects may occur, if they do occur they may need medical attention. Phenols . Although hypothermia was very common, especially in cats (90.9%), hyperthermia was frequently observed in dogs (21%). Phenol has a distinct odor that is sickeningly sweet and tarry. Check with your doctor immediately if any of the following side effects occur while taking phenol … Last updated on June 14, 2020 Home ... Cats lack the enzymes in their bodies that break down certain components of essential oils. Essential oils toxicity in cats: Everything you need to know. That is important information for all members. Because of cats' limited ability to metabolize carprofen via glucuronidation, the drug's elimination half-life (20.1 ± 16.6 hours)21 in that species is longer than in dogs. 2,6-diisopropyl phenol 2,6-bis(1-methylethyl)phenol Supplier Sponsors. For example, Novorapid contains 1.5 mg/ml of phenol and 1.72 mg/ml of metacresol. Systemic toxicity can result from skin or eye exposures. Consequently, use of the drug in cats poses a far greater risk of adverse effects. Here are Some Essential Oils that are Safe to Diffuse around Cats Some of these essential oils are void of the organic compound phenol and if any is however present, then it must have reduced in terms of its concentration to a level where it is bearable for cats.. Cedarwood Essential Oil. Acute keratoconjunctivitis sicca has been reported in some dogs after acetaminophen ingestion. Cats 1–2 U per cat q 12 hr. Examples of such components are phenols. Susceptibility of cats to phenol. Cats may experience toxicosis at dosages exceeding 50 mg/kg, but severe toxicosis was not seen in an experimental setting until repeated exposures greater than 80 mg/kg were administered. Food poisoning is another common cause of poisoning in cats. The toxicity of phenol . Along with its needed effects, phenol topical may cause some unwanted effects. Recombinant DNA origin human insulin. Acute toxicity (96 h LC50) of phenol was analyzed in the cat fish Mystus vittatus in static bio-assay over a 96-h exposure period using probit method. [8] Spruce Oil. Cats … The molecule consists of a phenyl group (−C 6 H 5) bonded to a hydroxy group (−OH). This monograph summarizes data pertinent to … Even dilute solutions (1% to 2%) may cause severe burns if contact is prolonged. The onset, severity and duration of toxicity is determined by the dose, route of exposure, physicochemical properties of the organophosphate (e.g. Toxicity of flufenamic acid in the cat Toxicity of flufenamic acid in the cat CARLISLE, CAROL H. 1983-10-01 00:00:00 Department of Veterinary Surgery, University of Queensland, St. Lucia, Queensland, 4067, Australia ABSTRACT Twelve cats were treated with dosages of flufenamic acid varying from 80 to 5 mg/kg daily. Dogs 0.25–0.5 U/kg q 12 hr. While most cases 2/7. Cats are probably a little more sensitive to onion toxicity than dogs are. Berje Inc. Where the world comes to its senses : Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals. But in cats, it can even cause severe liver disease or liver failure. [].Primarily, the values are clustered in the range of 250–500 mg/kg although the value reported in cats (80 mg/kg) is considerably lower [1,5].Lewis [] specifies values of 317 mg/kg for rats, 270 mg/kg for mice, and 500 mg/kg for dogs. 1961 Feb 15;138:197-9. I was wondering if anyone here was thinking about toxic substances present in insulin formulations. ERNST MR, KLESMER R, HUEBNER RA, MARTIN JE. In cats, toxicity can occur with 10–40 mg/kg. When you first arrive at the veterinarian office, she will begin by performing a physical exam. While previous investigations have concluded that in cats the gene for the phenol-type glucuronosyltransferase isoform has turned into a pseudogene because of several point mutations, evaluation of genomic information for snake species revealed that they have only 2 genes that may code for glucuronosyltransferase isoforms. Concentration. Hot oils like cinnamon, nutmeg, and thyme contain the highest levels of phenol and can be the most offensive to cats. MA was telling a member about the toxicity of Pine Sol to cats. Cats are also very sensitive to phenols and phenolic compounds, which can be found in some essential oils. J Am Vet Med Assoc. Phenol is an aromatic organic compound with the molecular formula C 6 H 5 OH. can also undergo several chemical reactions such as . I can't find an exact quantity of onions required to cause toxicity problems in dogs, but there are several case reports of onion toxicity and they involve whole onions or sizable portions of chopped onions (like a cup or more). Then, when cats groom, they ingest the cleaner which damages their liver and kidneys. The commercial product is a liquid. 735) established by the 1999 Joint FAO/WHO Meeting on Pesticide Residues (FAO, 1999). Disinfectant toxicity in cats is summarized in table 1. It is commonly used as a room deodorizer and can be used with other oils for an invigorating massage. The higher the concentration of the essential oil (i.e. Phenol poisoning can occur by skin absorption, vapor inhalation, or ingestion, and, regardless of route of exposure, can result in det rimental health effects. Other data on the toxicity of phenol and its derivatives were consistent with the results of the safety evaluation. Coal tar: Coal tar is found in products like cresols, creosote, and phenol, and it's included in household disinfectants. Primarily, the values are clustered in the range 250–500 mg/kg, although the value People have no problem with that. Joined Dec 21, 2005 Messages 2,155 Reaction score 2. Phenol vapor and liquid penetrate the skin with an absorption efficiency approximately equal to the absorption efficiency by inhalation. The higher the concentration of the essential oil (i.e. Mildly acidic, it requires careful handling because it can cause chemical burns. PMID: 13697246 [PubMed - indexed for MEDLINE] (1995). All forms of phenol cause irritation, and acute toxic effects of phenol most often occur by skin contact. The hospitalisation period was 1-3 … Eating garbage or feeding food which is out of date, improperly stored or improperly handled. 22. In the case of cats, poisoning happens by absorption through the skin, although ingestion does happen sometimes. Acute toxicity has been observed in man and experimental animals, resulting in muscle weakness, convul sions, and coma. Common drugs such as non-steroidal anti-inflammatories are some of the most deadly to cats. Cats have difficulty metabolizing certain drugs due to their altered liver metabolism, especially as compared to dogs and humans. Summary of Mammalian Toxicity Mammalian Oral Toxicity - Acute. And that is 1984! 2. Oral median lethal doses (LD 50) for phenol are listed in the HSDB [], Lewis [], and Berman et al. The cat shows remarkable sensitivity to the adverse effects of phenolic drugs, including acetaminophen and aspirin, as well as structurally-related toxicants found in the diet and environment. Cats are more susceptible to salicylate toxicity, because this species is deficient in glucuronidation pathways. When compared to dogs, cats are extremely susceptible to phenol toxicity since their liver lacks an important enzyme for metabolism of phenol. U-40. Phenol poisoning in the cat. Treatment in all patients was supportive and symptomatic, and the most commonly used anticonvulsants were diazepam and barbiturates; however, severe unresponsive seizures in three dogs had to be controlled with inhalant gas anaesthesia. Here we are – some 33 years later, still questioning if essential oils are killing cats, and reporting all over the place that it is a huge area of concern. Jul 9, 2006 #5 Z. zissou'smom … Side effects requiring immediate medical attention. Cases of toxicosis in this species are most often the result of inappropriate administration. This organic compound is present in many essential oils, making them unsafe to use around pets especially cats. Cats are deficient in an enzyme called glucuronyl transferase, which can be found in the liver and is responsible for breaking down Phenol. Phenol is caustic to the delicate paw pads. WILDLIFE TOXICITY ASSESSMENT FOR PHENOL 4 2.3 Summary of Mammalian Toxicity 2.3.1 Mammalian Oral Toxicity 2.3.1.1 Mammalian Oral Toxicity - Acute Oral median lethal doses (LD 50s) for phenol have been given in Lewis (1992), HSDB (2002), and Berman et al. Weaker solutions of phenol (25% to 50%) can be used to achieve lighter peels; however, the results are not better than TCA and there is still the risk for systemic toxicity. Top Cat. Renal injury is also possible. The Committee took note of the ADI of 0-0.4 mg/kg bw for 2-phenylphenol (No. This kind of poisoning causes the stimulation of the nervous system, weakening of the heart and liver damage. Applies to phenol topical: oromucosal spray, oromucosal suspension. Glargine (long-acting) Product Description. This enzyme protects animals from toxins or harmful substances like those scents from essential oil. The symptoms he may display are not commonly seen in anything other than a type of toxicity. 100%), the greater the risk to the cat. depends o n it s arom atic ring where benz ene ring itself . When ingested, NSAIDS can result in severe, acute kidney failure (ARF) and gastrointestinal injury/ulcers. 1976 Oct 16;99(16):319. Comments. 100%), the greater the risk to the cat. Methemoglobinemia and hepatotoxicity characterize acetaminophen toxicosis. “Even drugs known for toxicity in cats can be used safely if we are aware of and compensate for certain peculiarities.” That basically says it all. Since it has high phenol content, its use around cats is strongly discouraged because of the risk of toxicity. Commonly used in cats; not commonly used in dogs. Similarity of these genes with mammalian genes is <50%, and … It is a weak acid derived from phenol. Vitamin toxicity can also occur in cats who have been given vitamin supplements or cod liver oil. Some clinicians believe that for dogs, a starting dose of 0.25 U/kg is appropriate and 0.5 U/kg should be reserved for potentially challenging diabetics. I would like some more info on this. Basically, the higher the concentration of the essential oil (such as one not diffused with carrier oil), the higher the toxicity. Another plant similar to pine trees, the oil from spruces is known for its characteristic clean pine smell. Diagnosis of phenol and phenolic poisoning is either on a rule out basis or by witnessing it firsthand. This will allow her to view all of his symptoms and note all the abnormalities. Vet Rec. I clean with pine sol and never had a problem with my cats in 12 years. RELEVANT BACKGROUND INFORMATION 2.1 Explanation. You can taste and smell phenol at levels lower than those that are associated with harmful effects. Dodman NH, Bogan J, Thompson H. PMID: 982778 [PubMed - indexed for MEDLINE] Publication Types: Jul 9, 2006 #4 kitytize TCS Member. Could you direct me to a site. It is a white crystalline solid that is volatile. Newer modifications of phenol peels with reduced levels of croton oil have significantly reduced the amount of postoperative hypopigmentation, postoperative erythema, and scarring. Cats lack an essential enzyme in their liver and as such have difficulty metabolizing and eliminating certain toxins like essential oils. 1. Ingestion of the oil can cause seizures in cats. This essential oil is void of phenol and thus certified safe to diffuse around cats. , NSAIDS can result in severe, acute kidney failure ( ARF and. 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