You can go to 40PlusFitnessPodcast.com/327 and I’ll make sure to have links to both the Facebook group and to Dr. Lynch’s website and to the book. Because if you understand how your body works and why it’s important to breathe properly and why it’s important to eat certain foods and avoid certain foods at certain times; even healthy food you need to avoid at certain times, and I explain why – it will really make sense to you, especially when you apply it and you’re aware of the changes. These are really, really common problems. No, there are no side effects. Ari Whitten: A quick side note, I actually I got introduced by a friend of mine, Dr. Maya Shetreat-Klein, I don’t know if you know her but she and Robert are close friends so she actually introduced me. You can go to 40PlusFitnessPodcast.com/talk. Symptoms are not something that you push away and swallow a pill like Tylenol or antacids to say, “This symptom is irritating, I’m going on through my life.” It’s your genes are like, “Hey, yow, help.” They’re giving you insights to how to fix it, and Dirty Genes gives you those symptoms and then connect them to genes and I tell you what your genes are trying to tell you. Yeah, very good point, but yeah, so you just look for a prenatal that has both forms of active Folate which are L-methylfolate and Folic acid. There are genetic variations in this gene called DHFR that are known to be very, very slow at processing folic acid, and they’re very common actually. There’s only a time when you look back and wish you had started earlier. We’re going to have the bag of chips, we’re going to be walking down going for a walk with our significant other or our kids or our friends and we’re going to breathing car exhaust. And the fundamentals are air, food, water, shelter, and your mindset. Ari Whitten: So we had these strengths and weaknesses, weaknesses would be these people would be hypersensitive to a lot of different environmental chemicals but the strength might be because they’re hypersensitive they might react and pull away from it and notice it sooner than someone else and be less likely to develop a toxicity from it. Ben Lynch: Okay, well then if Curcumin does stimulate Nrf2, then it does, you’re right, then it does, that would speed up glutathione production and secretion. He has supported thousands of clients and trained thousands of physicians and health professionals across the globe in using insights from epigenetics to optimize health. And this gene has a big, big role to play here. Is this the right time for you? So again, go to 40PlusFitnessPodcast.com/talk. I thought that MTHFR was a gene that was like, “Oh my God, I’ve got this too, and it explains all my symptoms in the past, and my kids have it now, and I was all scared.” I was working with patients and myself and my family and I noticed I got better but if I took a bunch of L-Methylfolate, it got worse. It’s literally gumming up your genetics and your whole body. You had to almost have a computer science engineering degree to sit down and know how those dip switches work. That’s leafy greens and things like that. NOS3 (Nitric oxide synthase 3) Summary of NOS3 NOS3, also known as eNOS, produces nitric oxide in our blood vessels, which helps vasodilation and mediates formation of blood vessels, and promotes blood clotting by activating platelets ( R ). | Powered by WordPress, Clean those dirty genes with Dr. Ben Lynch. We have thousands and thousands of views on each one, and they’re a lot of fun. Associations for the risk allele (C) of this SNP include: Rheumatoid Arthritis [PMID 17009241], and,; cardiovascular mortality in high-risk patients [PMID 16979000] Supplements are simply a way to Spot Clean your Fast COMT. I love walking down the aisle in Home Depot and smelling all the fertilizers and pesticides, I just totally dig it. Dr. Ben Lynch: For sure, yeah, I’m glad you pulled that out too because you’re right, I do … We just briefly touched on it here, and then in the book, we expand on it more. I looked at my supplement shelf, looking for something to perk me up, and I was like, “No, that’s not it.” And so I reached for a glass, I filled it up with water. Our inputs for our own body are again just like the keys on a keyboard. Ari Whitten: … multi-standard multivitamins? We think of genes in this very static way, and what you’re saying is genes are really dynamic and that we have all these hundreds of genes that are being expressed differently from minute to minute depending on what we’re doing and what information they’re getting. I’ll be arriving I think on the 19th. And then they see a fad or something new, they jump on, and they see an opportunity in generic reports, and everybody is running them. We have the keyboard in front of us, and we have 26 letters to choose from, and those 26 letters have written how many books in this world? Why do you feel genetic testing isn’t so important for everyone to do and why someone shouldn’t rush out to try to fix this gene or that gene? They were like, “Those look good. And if you’re not secreting stomach acid, you’re not breaking the food down. Vitamin B2 : Riboflavin phosphate: Vitamin B2 is one of three co-factors required by NOS3 to function correctly 8. I picked genes, period. Ari Whitten: Just to digress on that point for a second, I’m curious what your thoughts are on pregnancy in particular where so many doctors are of this opinion that you need to supplement with folic acid. So you’ve got to make sure that your air is clean. I move past the impulse and think what it’s actually going to do to me. What you need to know about folate is, I think it’s Latin – “folar”, if I’m not mistaken, or “folium”, and it means “leaf”, “foliage”. But the point that I want to make is that folic acid is a known contraindication, meaning do not do it for a condition called cerebral folate deficiency. I talked with him all the time and he’s a phenomenal individual and author of the paper. Glutathione is just coming along and trying to defeat the purpose of the chemotherapy so that why having a glutathione problem for chemo is not good. Breathing is super, super important. NOS3, the gene that can create heart issues. Gene target information for NOS3 - nitric oxide synthase 3 (human). X-ray was developed and we were x-raying people’s shoe size feet for the perfect fit for a shoe, right? I would reduce it because you will get yourself more chronic fatigue and problematic. I really appreciate it. It’s slightly not perfect. The manufacturer told me to delete it because I was going to irritate the FDA, and I was like, “No, I’m actually in support of what the FDA is doing.” Because when you look on a supplement bottle … Let’s see if I have one here, I don’t think I do. And that’s where I wanted to start this discussion today. Dr. Ben Lynch: Yeah, so but basically the Cell danger response is your body’s ability to sense danger whatever it is, a chemical in the air, an infection, a stressor, and your body will go into protective mode and will shift the whole system immediately. Even if your genes are born dirty like NOS3, you have a problem in this gene and you’re born with that, you need to know this because you can take action and reduce your susceptibility to cardiovascular disease and neurotransmitter problems, neurological issues. Other people are going to need to be doing it for six months before they move on to the next section. We don’t have malaria here really in our environments, right, so when you live in certain areas, there is still malaria in certain areas so that is an issue. Ari Whitten: Beautiful and you briefly glossed over something there that is really important and is actually one of the reasons that I’m a fan of your book. Now, in your book, you have the 4-week Clean Gene Protocol. Folic acid is a synthetic form of folate. You know Vitamin C, you know Vitamin E, you might know Resveratrol and these other things, but glutathione is really the big kahuna, that’s what you want and have plenty of. And I’m just not going to feel good, so I don’t eat it. Then we’ve got NOS3, and this one’s super important. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. I was like, “Wow,” and so if you give something with the belief that it’s going to only help, you are creating bias. Ari Whitten: Those things that you just mentioned are going into translate into maybe for example if DNA repair is increased, it might translate into decreased susceptibility to maybe certain kinds of cancer. But when it comes to our actual health, we have a lot of say in what our genes do or don’t do for us. I almost dedicated the book to… It was going to say something along the lines, “This book is dedicated to those who read and actually implement what they read.” Because you can read all you want, but if you don’t actually implement, no book is going to serve you and you’re going to be complaining that the book didn’t help you out. We’re trying to fix our health and we think that the companies are out there providing us a tool to help us do that, but that tool is actually the key that sticks. Just yesterday I walked into the house and I was like, “God, I’m tired.” And I opened the fridge looking for something to give me a perk up. Now you’re on this side, now you’re in a whole new world that you’re not familiar with. NOS3: Gene description i. Nitric oxide synthase 3: Protein class i. Cancer-related genes Disease related genes Enzymes FDA approved drug targets Plasma proteins: Predicted location i Intracellular: Number of transcripts i. I’ve talked to a few people lately and it’s kind of interesting. In fact, the last one I did was on how to put together a fraud investigation. (Note: Also make sure to sign up for the Dirty Genes Summit. It’s great for business, it’s great for convenience, but you are literally eating dust without nutritional value. So that was really what frustrated me – just the whole concept of, we’re trying to do the right thing. I’m here today with Dr. Ben Lynch, with a conversation that I’m very, very excited to have. It’s fighting for us. That is one problem is Folic acid is everywhere and pervasive in the environment, and I strongly believe that no one should be eating folic acid because it’s not just the MTHFR gene that’s a problem, it’s all the other Folate genes too. Just know that now your threshold has just gone from here to here, and make up for it the next couple days or the next week. One of my neighbors has decided to host a little pop-up party for the 4th of July. Ultimately when we eat something or see, hear, taste, or touch something – we are sending signals that get all the way down to the surface of the cell, which sends a signal down into the nucleus, which tells certain genes to turn on, certain genes to turn off, and they produce something because of that. I’ll get caught up. Ari Whitten: It’s a little blurry, I don’t know if the camera can focus? It’s like the soak and scrub 4-week protocol for free for you. So folic acid is the key, and the doorknob is the receptor or the folate-binding protein. Dr. Ben Lynch: It’d be interesting to look that up because SNPs to me are like the radio antenna on top of a skyscraper. I’m recording this on the 4th of July. And then if there’s a reason, we can look at these other supplements as just that, a supplement. Then there’s another form called Folinic acid and Folinic acid works on repairing your DNA and helping produce your blood cells, and your platelets, and your white blood cells, your red blood cells, and your energy, and your ATP, and your GTP, and it helps repair your DNA as it’s damaged. (1996) studied a marker closer to the 5-prime end of the NOS3 gene, the 27-bp repeat in intron 4, in relation to coronary artery disease. Nitric oxide synthase 3 G894T gene polymorphism and response to skin hyperemia are reported. And realize that by cutting out something that we thought was bad it might actually increase the risk for other diseases that we were unaware of. So it literally is “above the genetics”, and that doesn’t really help you out that much, but what you need to know is genes are buried inside your nucleus, which is buried inside your cell, and your cell contains all this stuff inside a cell membrane. That’s it, it’s a simple concept that we can keep our cleans oiled and well machined. So if you feel great, stop, and then if you take it right away and you feel worse, you should probably stop. If you don’t, you have seizures, you have epileptic seizures, you have neurotransmitter deficiencies. I just found that fascinating that there might be this kind of strength to this to maybe not having as effective of a glutathione production system. And will get in there and will kill the virus or the bacteria or the whatever’s going on, and then after that insult is gone, the cell danger response will quiet and everything will start going back to repair mode again. Ari Whitten: Oh yes, for Betaine anhydrous trimethylglycine. But for most of us, we have now removed … We have the MTHFR gene but we’re no longer living in malaria-infested areas, and we have processed food and so on. I’ve got that done and I’m about halfway through with putting together my slides for my presentation. Folic acid is one of those things that was literally invented by humans, because we decided, geniusly, to have basically bread flour, stripped of all nutrients, so it’ll live on the shelf longer. Water can kill you, air can kill you, right? Your body is trying to protect you and you have no energy and you’re GST/GPX genes are trying to work for you, but you keep insulting it. Dr. Lynch (12:44): Yeah, it’s got to be an odd number for Feng Shui in the book. It’s sold everywhere and it’s been translated into 11 languages. Dr. Lynch, thank you so much for being a part of 40+ Fitness. Thanks, Ari. But what happens is that folic acid has no human physiological benefit at all in the human body. You can’t start a business from nothing, really, and expect. There are people that are taking literally 30 milligrams of Deplin or L-methylfolate, 30 milligrams, not only is that super expensive, it’s dumb. 39:40 Is there a particular order for cleaning genes? We have to appreciate that our body is constantly working on our behalf and so we have to take the actions that support the machinery as well as we can. When you’re breathing this, you’re using up your glutathione, and that gene is very, very easily dirtied. It’s everywhere – in our building materials and furniture, and your clothing, your carpets, your cabinets, your mattresses. There has to be some evolutionary benefit to having these things, so what are they? If glutathione levels are low and/or methylation isn’t working well, then neither is NOS3. Now, we all know Folic acid and we think that if we take a supplement with Folic acid or eat a food that’s enriched with Folic acid, we’re doing ourselves a favor, well you’re not. Lose weight, get stronger, feel younger with Coach Allan, SPONSOR: Join John Assaraf’s Free Brain-a-Thon, SPONSOR: Get Your Lab Results From the Comfort of Your Own Home, SPONSOR: Get a Free Audiobook From Audible, Copyright text 2020 by . When you want to clean your kitchen, you start with the dishes – they’re glaring there on the counter. But I want people to understand that if you’re born dirty with these genes, you’re not locked into a problem, they’re just already born dirty. And the genes in the human beings do not work fast to process folic acid. Dr. Ben Lynch: Yeah, I appreciate your time and I love the fact that you’re in total line with this too and it’s great to finally find a comrade to help change the paradigm for people to get better, because treating SNP, they won’t get better. I had Dr. John Day on the show for episode 272. Ben Lynch: Yeah, you see the parentheses with trimethylglycine? Dr. Ben Lynch: Yeah, thank you, and I thank her a lot for that too because anytime I wrote something, because I would write the chapters and send it to her and she’d just get on the phone and is like, “I don’t get this.” She goes mad at me and she goes, “What are you talking about?” So it was great. Even for me, been studying this field all the time, I still had this little piece of doubt in my mind, “Well maybe I don’t know enough about pregnancy in particular, and maybe they’re right, maybe we should supplement with this.” But eventually, I actually made the decision, “No, you’re not going to take that, what we’re going to do instead is we’re going to make sure that you’re eating tons of Folate in your diet on a daily basis. You clean those, you put them away. Then see what to do about it here. Now, that’s born dirty, so you got these from your mom and dad. I’ll send you a conference call. Ari Whitten: Very cool. Epigenetics is a very complex topic, but he does a really good job in his book Dirty Genes on explaining how all this stuff works in a way that’s applicable. I see that all the time with … Well not all the time, but I see that sometimes with people going along the freeway and their brake lights are on the whole time. NOS3 (ECNOS, eNOS) protein expression summary. You’re probably right, there’s probably like 9.9 times out of 10 that it’s synthetic folic acid because the companies that are utilizing the good folates are going to tell you. But it’s the fundamentals, you look at any team who excels, they know the fundamentals amazingly well, they pass well, they shoot well, they work as a team well, they do all the basics. I’m talking 1,500 years ago, their life was totally different than ours, yet we still have their DNA for the most part. I mean you buy a car and it’s brand new, and that car we can say it’s your genes. You can try it, and if you’re lucky, fantastic. Genes do work, and if you give your genes healthy food, they can do healthy work. If any of those other six genes are dirty, this NOS3 gene is … Yeah, your folate is important for pregnancy and breastfeeding and so on. So here you are your cells are producing energy like crazy and then there’s an insult, there’s an infection, or there’s a chemical. That’s why this … I wonder what the definition of the foundation is actually to be curious. Can you take just a moment to explain folate, why it’s important, and actually what the difference is between that and folic acid? It was so good when I presented on it. Are you going to cut corners that are marked 20 miles an hour, are you going to go around 50? There are a lot of people that Google “folic acid”, so if I can make a website FolicAcid.com, and I will be, I’m going to be garnering a lot of attention and making a lot of noise with the help of social media. Question to ask? Allan (0:00): On episode 327 of the 40+ Fitness podcast, we meet Dr. Ben Lynch and discuss his book Dirty Genes, a breakthrough program to treat the root cause of illness and optimize your health. Dr. Lynch (22:49): Let me drive this point home with the final blow. Dr. Ben Lynch: Man, I love your questions and you’re very well read, and well researched, good man. I don’t go to grab those chips, and I know that they’re going to knock down my resiliency even more, so I’ll be more stressed because now I’m in that vicious cycle of stress, crap, stress, crap, stress, crap, where I can’t get out. They’re tired of hearing these but what I do is I say, “Hey, these are the genes which really help you calm down or these are the genes which predispose you to stressors, and this is why you’re so susceptible to stress may be compared to someone else, and this is how you fix it.” I will be flippant a bit about saying, “Yeah, you got to do what your grandma told you but at the same time I’ll give you evidence and tools to make you understand of how to correct these things.”. Simply use our contact address and we’ll get back to you within 24 hours. So what do you do? So they throw a couple of supplements together and they try to label them and they start recommending stuff on this. And then you have PEMT, which really no one talks about, and PEMT’s job is to help make your cell membranes. The biggest reason is because when you support these seven, they help clean up all the other genes in your body. But on the flip side, if you are that person who is super sensitive to chemicals and if you have these glutathione genes you will be very likely that you will be, excuse me. NOS3, the gene that can create heart issues NOS3 affects your production of nitric oxide, which is a major factor in heart health, affecting such processes as blood flow and blood vessel formation. . Your StrateGene report will still provide Test to see if your NOS3 is dirty here. Dr. Ben Lynch: You’re not resilient anymore, and it’s the same thing with your cell danger response, and so if you are caring for your body and you’re making the right decisions, then yeah you might insult it with a late night, or you might insult it with a Thanksgiving dinner and a bunch of alcohol and having a party with your friends, that’s cool, enjoy yourselves. I can’t believe that the vitamin manufacturers are allowed to feed us this stuff. It looks good. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. What are some of the strengths and I guess the … Well, let’s talk about some the weaknesses of the MTHFR not having have the most optimal SNP. I’m going to enjoy it.” And if you want to stay up late and watch a movie, just know how you’re going to feel tomorrow and don’t blame others for your bad day. You can go to Ketofest.com and learn more there. I said, “Are you serious?” And he goes, “Yeah, we need a 30-day program.” I said this is a program to help people clean their genes for the rest of their life; this is not a 30-day thing. There’s so much emphasis on breast cancer, and there should be, but the number one killer actually in women is cardiovascular disease. It’s going to make me feel worse if I take it when I feel these symptoms.” And so, I take a mental file. Or maybe I can’t help you, but we can kind of diagnose that right there. So, really worth a listen. Genes, we all have them. Getting back to some of these genes, I guess sticking with MTHFR, what are some of the practical steps that someone can take to help address that issue? It’s like the last thing you work on, and I’ve learned that the hard way, because believe me, I tried to go straight to the SNPs because people come to me with their genetics because I was the genetic expert, and I would try to fix their [inaudible], trying to fix their CMT and sometimes it worked, but most of the times it didn’t. So they’re getting it, and they make their own choices. And what it’s basically telling me is that my environment is super, super important, and if I don’t clean up my environment, my genes are going to be dealing with all these chemicals and not working on my health.” And he’s absolutely right. From the presenters to 1,500 people. Food contains what? It said, in the talking about genetic testing, so you said, “What if you’ve had genetic testing already and you want to head straight to fixing your problem genes?” Then you said, “Trust me, don’t.”. Gas and the fundamentals are air, food, it ’ s get better food, your mattresses time my. 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